Dr. Ghulam Mustafa
I am serving as Assistant Professor in Department of Chemistry, University of Gujrat, Punjab Pakistan since August, 2008. I have earned my PhD (Chemistry) degree from GC University, Lahore. I did M.Phil and M.Sc. Chemistry studies from the same institution and BSc (Zoology, Chemistry, statistics) from Punjab University, Lahore. I have performed a part of my synthetic work in Applied Chemistry Research Centre of PCSIR Laboratories Complex, Lahore and biological studies in School of Pharmacy, University of Punjab, Lahore. I have more than 20 years of teaching and research experience. I started my carrier as chemist in Research and Development Cell of Qarshi Industries (pvt), Limited (November, 1999- September, 2001). Later on, I joined Higher Education Department, Punjab as Lecturer in Chemistry (August, 2002- September, 2007). I joined Department of Chemistry, University of Gujrat in September 2007. I have the hounour of establishing labs and procurement of high-tech equipment including GC-MS, HPLC and Atomic Absorption Spectrophotometer for Department of Chemistry, University of Gujrat. My research interest is in synthesis of heterocyclic compounds of pharmacological importance, green chemistry and environmental issues. I am also serving as the Incharge of Atomic Absorption Spectrophotometer and provide analysis facilities not only to M.Phil and PhD scholar of chemistry but also to the students of Botany, zoology and environmental science. I have successfully completed NRPU research project title “Synthesis of Novel Potential Anti-inflammatory Agent Derived from Pyrazolone” funded by HEC. I have supervised the research work of 22 students of M.Phi.
AREAS OF INTERESTS:
• Organic Synthesis
• Heterocyclic Chemistry
• Pharmacological applications
• Structure-Activity Relationship
• Green Chemistry
- PhD,Goverment College University , Lahore
- M.Phil,Goverment College University , Lahore
- M.Sc,Goverment College University , Lahore
- BSc,University of Punjab
- Director Sports Board University of Gujrat. Directorate of Sports, University of Gujrat
- Member Advance Studies & Research Board (ASRB), University of Gujrat. to date
- Member of study leave committee, University of Gujrat. to date
- Member Self Assessment Team, Department of Chemistry, University of Gujrat to date
- Member Board of Studies (BOS) Department of Chemistry, University of Gujrat. (2016-2019) Duration( 2016-2019)
- Member Faculty Board, Faculty of Science, University of Gujrat. Duration (2016-2019)
- Focal Person QEC, Department of Chemistry, University of Gujrat to date
- President Bazm-e-Nazir Society Roll of Honor, New Hostel, GC University Lahore. Session 1997-99
- Vice President Duni Cliff Chemical Society GC University Lahore. Session 1997-99
- Incharge Organic Chemistry Lab, GC University, Lahore Session 1997-99
| Student Name | Degree | Title | Status / Completed Year |
|---|---|---|---|
| Saba Riasat | MS | Electrochemical study of nickel based chalcogenides nanoparticles In recent years, the exploration of nanomaterials has gained substantial traction across various scientific disciplines as it has unique physical and chemical properties. Among these materials, nickel chalcogenide nanoparticles have emerged as a promising class with a great range of applications in energy storage, catalysis, medicine, biology, environmental sciences, and optoelectronics. Variety of synthetic methods employed to synthesize these nickel based chalcogenides nanoparticles such as hydrothermal, solvothermal, chemical decomposition, thermal decomposition etc. For the characterization of structural and functional properties, and evaluating their performance in different applications, different techniques are used. | 2024 |
| Asma Shoukat | MS | Synthesis, Characterization and Assessment of Anti-Inflammatory Potential of Substituted Pyrazoles In this research work, the derivatives of 1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (114) were prepared by reacting it with different substituted sulfonyl chlorides as given in scheme. The reaction was carried out in an alkaline medium under reflux and sulfonyl moiety was attached to the nitrogen of pyrimidine and pyrazole ring of allopurinol and produced compounds (115a-k). The produced derivatives were characterized using FTIR spectroscopic technique. All the synthesized analogues were assessed for their anti-inflammatory activity through BSA denaturation assay and evaluated for antioxidant activity through DPPH radical scavenging assay respectively. Remarkably, most of the derivatives exhibited significantly improved anti-inflammatory properties. Notably, compound (115j) known 1,5-bis-(4-chloro-benzenesulfonyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one and compound (115e) named 1,5-bis-(4-nitro-benzenesulfonyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one demonstrated the highest BSA denaturation inhibition potential of 80.96% and 80.78% respectively close to standard at highest selected concentration i.e., 3.5 mg/mL. While compounds 115a, 115g and 115k also showed good anti-inflammatory activity. In antioxidant assay, compound 1,5-bis-(4-bromo-benzenesulfonyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (115a) with 55.77% inhibition showed highest activity towards radical scavenging assay among other derivatives but comparatively very less as compared to standard. The selected compounds 115a, 115b, 115c and 115f exhibited low to moderate antioxidant activity at highest selected concentration i.e., 3.5 mg/mL. | 2024 |
| Syeda Khadija Bukhari | MS | Synthesis of Substituted Pyrazoline and Evaluation of Their Anti-Inflammatory Potential In this research work, a series of pyrazoline pharmacophores (123a-j) was synthesizedby reacting chalcones (122a-j) with hydrazine hydrate. Methyl-2-pyridylketone alongwith benzaldehyde was used to synthesize pyridine-based chalcones. The precipitatesof the ketones thus formed were further reacted to hydrazine hydrate giving 2-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)pyridine and its different derivatives. The extentand completion of reaction was confirmed by thin layer chromatography. Chalconesformed as intermediates as well as pyrazoline derivatives were subjected to FTIRanalysis which confirmed. The series of chalcones and pyrazolines formed werestudied for anti-inflammatory potential through in-vitro BSA denaturation assay. Mostof the compounds were found to have anti-inflammatory activity. Among thechalcones (intermediates), 122h was found to have maximum anti-inflammatorypotential (81.09%) amongst others. The pyrazoline derivatives were also found tohave anti-inflammatory potential. However, the derivative 123e (85.01%) was foundclose to the standard (91.76%) in anti-inflammatory potential. Evaluation of anti-oxidant potential of the synthesized compounds was done by DPPH RadicalScavenging assay showing that 122a exhibited 83.10% activity being the closest togallic acid (standard) which is 87.99%. The pyrazoline molecule 123e possessed81.20% antioxidant potential. This study aims towards development of pyrazolinederivatives with a simple synthetic route followed by their evaluation of anti-inflammatory potential. | 2024 |
| Sabahat Noureen | MS | Synthesis and Electrochemical Characterization of Cobalt Based Nanoparticles and Its Composites Cobalt based nanomaterials, specifically Cobalt Oxides (Co-O) and Cobalt Sulphides(Co-S) find their extensive applications. In this research work the synthesis of CobaltOxides (Co-O) and Cobalt Sulphides (Co-S) was carried out successfully by usingprecipitation method. The prepared NPs were doped with Nickel metal by the aid ofImpregnation method. The prepared nanomaterials and their respective Ni-dopedvariants were subjected to characterization. The characterization techniques includingFTIR spectroscopy, UV-Vis Spectroscopy and Fluorescence studies not onlyconfirmed the successful synthesis of the desired nanomaterials but also predictedtheir potential properties and applications. The Electroanalytical analysis of thematerials using CV, GCD and EIS consolidated the electrochemical properties of thematerials. This analysis long-established the use of these cobalt based nanomaterialsin energy storage devices. this study also explored the photocatalytic activity of theCobalt based NPs beside their electrochemical characteristics. The degradation of theReactive Yellow dye (Y-130) was performed, and the results endorsed the positiveeffect of Ni-doping as it enhanced the photocatalytic activity of the materials. | 2024 |
| Nimra Nasir | MS | Synthesis of Selected Pyrazole Derivatives and Evaluation of their Anti-Inflammatory and Carbonic Anhydrase Inhibition In this research work, the derivatives of 4-[5-{p-(hydrazinylcarbonyl)phenyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (125) were prepared by formation of its Schiff’s bases with different aromatic aldehydes as given in scheme-3.1. The preparation of compound (125) was done by oxidation of celecoxib, followed by its esterification and hydrazinolysis at its methyl position. The intermediate (125) was then refluxed with respective substituted aromatic aldehyde to yield Schiff’s base derivatives. The synthesized compounds were characterized using FTIR spectroscopic technique. All the synthesized compounds were evaluated for their anti-inflammatory, antioxidant, carbonic anhydrase inhibition and anti-bacterial potentials using protein denaturation assay, DPPH radical scavenging assay, stop flow CO2 hydration method and disk diffusion method respectively. Most of the synthesized compounds showed anti-inflammatory activity amongst them, compound 126h exhibited highest (76.44%) while, compounds 126i, 126k and 126l showed activities close to standard. The selected compounds 125, 126c, 126i and 126k showed highest activity at highest selected concentration i.e., 4 mg/ml. In antioxidant assay, compound 126e with 92.24% inhibition showed highest activity towards radical scavenging assay. The selected compounds 125, 126c, 126i and 126k exhibited highest inhibition at highest selected concentration i.e., 4 mg/ml but amongst them, compound 126c caused inhibition very close to standard at same concentration. The result of CA inhibition activity showed that only compound 126h had the highest % inhibition with KI (7.9nM). However, in anti-bacterial activity, compounds 126f and 126j showed highest growth inhibition i.e., (18.5±1) & (18±1) respectively towards Escherichia coli and compounds 126b and 126c showed same and highest (15±1) growth inhibition towards Bacillus subtilis. | 2023 |
| Jaweria Farree | MS | Synthesis, Characterization and Assessment of Biological of Selected Hydrazide Derivatives Various derivatives of hydrazide have been synthesized in this research work. Compound (106) has been synthesized by condensing bezafibrate ester (methyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropanoate) with hydrazine hydrate. The compounds 136-151 were synthesized by reacting compound (106) with different substituted aromatic aldehydes (a-o) in presence of acidified ethanol. The compound (151) was prepared by carrying out a cyclization reaction using KOH, carbon disulphide and hydrazine hydrate. Reactions’ progress was monitored by using TLC. FTIR and UV-visible spectroscopy was used for characterization of compounds. The synthesized compounds were screened for their antibacterial and antifungal properties. S. aureus and E. coli were the strains used in antibacterial activity and result revealed that none of synthesized compound showed activity against S. aureus while low activity (6±0.02) was exhibited by few synthesized derivatives against E. coli. In antifungal assessment, A. flavus and A. fumigatus strains were used. The results revealed that synthesized compounds possess moderate (8±0.1 to 11±0.05) to low (6±1) antifungal activity against A. flavus and moderate (8.5±0.03 to 11.5±0.05) against A. fumigatus. | 2023 |
| Raja Hasnain Ahmad | MS | Assessment of Anti-inflammatory and Carbonic Anhydrase Inhibition of Selected Substituted 1,2,4-Triazoles In this research, we synthesized derivatives of 4-{5-[4-(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}benzenesulfonamide (210) using Scheme-3.1, involving a condensation reaction with various aromatic aldehydes. To begin, Compound (209) was prepared through a sequence of chemical steps, starting with the oxidation of celecoxib, followed by esterification and hydrazinolysis, ultimately,yielding‘4-{5-[4-(hydrazinylcarbonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}benzenesulfonamide’(209). The intermediate (208) was further subjected to reflux with alkaline carbon disulphide and subsequent hydrazinolysis to produce compound (210). The synthesized compounds were characterized through the application of FTIR spectroscopic technique. These newly created compounds underwent screening for their anti-inflammatory activity through BSA denaturation assay, antioxidant capabilities through DPPH scavenging assays, carbonic anhydrase inhibition potential via stop flow CO2 assay and antibacterial activity through disk diffusion assay. Remarkably, most of these derivatives exhibited significantly improved anti-inflammatory properties. Notably, Compound (210h), known ‘4-(5-(4-(4-(3,4-dichlorobenzylideneamino)-5-mercapto-4H-1,2,4-triazol-3-yl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, demonstrated the highest protein denaturation inhibition potential at 97.15%. Conversely, Compound ‘4-{5-[4-(4-amino-5-sulfanyl-4h-1,2,4-triazol-3-yl)phenyl]-3-(trifluoromethyl)-1h-pyrazol-1-yl}benzenesulfonamide’ (210) exhibited the highest antioxidant activity of 97.43% and compound,4-[1-(4-sulfamoylphenyl)-3-(trifluoromethyl)-1h-pyrazol-5-yl]benzoic acid’(207) demonstrated highest carbonic anhydrase inhibition activity (KI; 35.7nM) among selected compounds. For E. coli the highest antibacterial activity 19.5±1.5mm was shown by 210l while the lowest 6±1.5mm was by 210b while for Bacillus subtilis the highest activity was demonstrated by 210j. | 2023 |
| Nukhba Shehzadi Mir | MS | Synthesis, Characterization and Biological Evaluation of Derivatives of 1-phenyl-1H-pyrazol-5(4H)-one In this study, the various derivatives of 1-phenyl-1H-pyrazol-5(4H)-one (1) have been synthesized by condensation reaction with a variety of aromatic aldehydes under acidic condition (Compounds 2-8). Compound 1 was prepared by the reaction of phenyl hydrazine and ethyl acetoacetate in acidified ethanol. The compound 2-(3-methyl-5-oxa-1-phenyl-4,5-dihydra-1H-pyrazol-4-yl)acetyl chloride (9) was prepared by reaction of chloroacetyl chloride with compound 1 followed by its hydrazinolysis to give 2-(3-methyl-5-oxa-1-phenyl-4,5-dihydra-1H-pyrazol-4-yl)acetyohydrazide (10). The synthesized compounds were characterized by FTIR and UV-Vis spectroscopic techniques. The antibacterial assessments of these compounds were carried out against E. coli, S. aureus and P. aerugiosa. The compounds 2, 3 and 9 have shown greater inhibition against certain strains than the parent nucleus (1) of bacteria synthesized compounds have shown moderate antibacterial activity against the tested strains of bacteria. Compound 1 has shown inhibition zone 6mm, 9mm and 7mm against E. coli, S. aureus and P. aerugiosa respectively. Amongst the derivatives the compound 2 has shown the inhibition zone 10mm and 11mm against E. coli and S. aureus respectively. Compound 3 has shown the zone of inhibition 8.66mm against P. aerugiosa respectively. | 2021 |
| Maryam Ashfaq | MS | Synthesis of Pyrazolone Derivatives from Substituted Hydrazide, their Spectral Studies and Assessment of their Biological Potential This study is based on the synthesis of different pyrazolone derivatives from selected substituted hydrazides. The synthetic method was focused on the conversion of substituted carboxylic acids (1a-1h) into respective esters (2a-2h) in acidified methanol. These esters were used to prepare carbohydrazides (3a-3h) by using methanol and hydrazine hydrate. These carbohydrazides were reacted with ethyl acetoacetate under highly basic conditions (KOH/Et3N) in methanol to afford respective targeted pyrazolones (4a-4h). The progress of reactions was monitored by taking TLC on occasional basis. The synthesized compounds were characterized by melting point and FTIR. The screening of these compounds was carried out for evaluation of their anti-bacterial potential. The antibacterial assay was carried out against M. luteus and B. halodurans. The results revealed that 2-[2-(2-fluoro-biphenyl-4-yl)-propionyl]-5-methyl-2,4-dihydro-pyrazol-3-one (4a) and 4-{5-[4-(4-methyl-5-oxo-4,5-dihydro-pyrazole-1-carbonyl)-phenyl]-3-trifluoromethyl-pyrazol-1-yl}-benzenesulfonamide (4c) possessing fluoro groups to be most potent among synthesized derivatives with zone of inhibition 7-19 mm respectively. 4a was found to be more biologically active with inhibition zone of 19mm, and 10mm against M. luteus and B. halodrans respectively. Among tested compounds only 2-[2-(4-isobutyl-phenyl)-propionyl]-5-methyl-2,4-dihydro-pyrazol-3-one (4b) was found to be inactive against B. halodrans. | 2021 |
| Zahra Bibi | MS | Synthesis and Characterization of Substituted 3,5-Diphenyl-4,5-dihydro-1H-pyrazole Derivatives and Evaluation of their Antibacterial Potential In this study, the different derivatives of pyrazoline have been synthesized by condensation of 4-(5-(4-(hydrazinecarbonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (4) with different chalcones (5a-j) in glacial acetic acid (6a-j). 4-(1-(4-sulfamoylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)benzoic acid (2) was synthesized by the oxidation of celecoxib using aqueous alkaline KMnO4 on heating. The compound (2) was esterified in acidic methanol to obtain 4-(1-(4-sulfamoylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)benzoate (3) followed by hydrazinolysis to produce the required carbohydrazide4-(5-(4-(hydrazinecarbonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (4). Furthermore, esterification of (2) is followed with few drops of sulphuric acid in methanol to get compound (3). To obtain compound (4) reaction of compound (3) was carried out in methanolic hydrazine hydrate. The chalcones used in this study were obtained by condensation of aromatic aldehydes and ketones in alcoholic potassium hydroxide (5a-j). The compound 4-(5-(4-(3-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (6b) was prepared by reaction of compound (4) with 4-chlorochalcone (5b). The synthesized compounds were characterized by melting point and FTIR spectroscopic technique. The antibacterial assessments of these compounds were carried out against Micrococcus luteus and Bacillus haloduran. Compound 6g showed highest inhibitions for the bacterial test strain of Bacillus haloduran and compound 6f showed highest inhibitions for the bacterial test strain of Micrococcus luteus. Compound 6g and 6f has shown inhibition zone 11mm and 13mm against Bacillus haloduran and Micrococcus lotus respectively. Compounds 6b and 6d were found to be inactive against both strains of given bacteria i.e., M. luteus and B. haloduran. | 2021 |
| Samun Zia | MS | Induction of 1,3,4-Oxadiazole Motif in Selected NSAIDs: Characterization and Biological Evaluation Abstract | 2021 |
| Hadia Khawar | MS | Synthesis, Characterization and Biological Evaluation of Substituted Pyrazolone Derivatives In the present study, the pyrazolone derivatives have been synthesized from 3-methyl-1H-pyrazol-5(4H)-one (1) and 1-(2,4-dinitrophebyl)-3-methyl-1H-pyrazol-5-(4H)-one (2). In order to accomplish this work, ethylacetoacetate was reacted with hydrazine hydrate (Scheme 3.1) and 2,4-dinitrophenyl hydrazine (Scheme 3.2) to prepare intermediates (1) and (2). These intermediates were refluxed with different aromatic aldehydes in the presence of acidified ethanol. The synthesized pyrazolones (1a-1g) and (2a-2l) were characterized by FTIR and UV spectroscopic techniques. These derivatives were further evaluated for enzyme inhibition against Acetylcholinestrase (AChE) and antioxidant activity at 400nm and 517nm respectively. The result of the activities revealed that the compound 4-(4-methoxybenzylidine)-3-methyl-1H-pyrazol-5(4H)-one (1c) (97.68%) and 4-(4-bromobenzylidine)-1-(2,4-dinitrophenyl)-3-methyl-1H-pyrazol-5(4H)-one (2e) (95.43%) showed highest inhibition against the AChE while 4-(2-hydroxybenzylidene)-3-methyl-1H-pyrazol-5(4H)-one (1g) showed highest antioxidant activity (92.24%). | 2019 |
| Yawar Mehmood Butt | MS | Synthesis, Characterization and Bioavailability Exploration of Derivative of 4-(5-p-tolyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide In this research work Celecoxib, (4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide), has been used to synthesize the 4-[1-(4-Sulfamoylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]benzoic acid (2) by oxidation of its 4-methly group with alkaline KMnO4 scheme-3.1. Methyl ester (3) and carbohydrazide (4) derivatives were prepared by esterification with acidified methanol followed by its hydrazinolysis respectively. The characterization of the synthesized compounds was carried out by using FTIR and UV-Visible techniques. Bioavailability studies of the synthesized compounds (1,2 and 4) was carried out by spiking with human plasma. HPLC analysis was performed for assessment of reaction of synthesized compounds with the human plasma. Celecoxib was taken as reference for both the acid (2) and the carbohydrazide (4). The compound 4-[1-(4-Sulfamoylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]benzoic acid showed least retention time than those of carbohydrazide and celecoxib. Celecoxib, being non-polar, showed maximum retention time when spiked with human plasma. | 2019 |
| Tayyaba Sarwar | MS | Synthesis, Characterization and Biological Evaluation of Substituted 1,2,4-Triazoles In this study, the derivatives of 4-{5-[4-(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}benzenesulfonamide (5) were prepared by condensation reaction with different aromatic aldehydes using scheme 3.1. Compound (5) was prepared by oxidation of celecoxib, followed by esterification and hydrazinolysis to give 4-{5-[4-(hydrazinylcarbonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}benzenesulfonamide (4). The intermediate (4) was then refluxed with alkaline carbon disulphide followed by hydrozinolysis to synthesize compound (5). The synthesized compounds were characterized using FTIR and UV-Vis spectroscopic techniques. All the synthesized compounds were screened for their antioxidant assay and enzyme inhibition potential using DPPH scavenging and Ellman esterase assay respectively. Most of these derivatives showed enhanced antioxidant properties, amongst them, compound (5i) 4-(5-(4-(4-(3-nitrobenzylideneamino)-5-mercapto-4H-1,2,4-triazol-3-yl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide showed highest antioxidant inhibition potential (97.52%). Whereas, compound 4-{5-[4-(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}benzenesulfonamide (5) with 97% inhibition showed highest AChE inhibition potential. | 2019 |
| Abida Parveen | MS | Investigation of Toxic Elements in Solid and Ground Water Around the Industrial Landfill Area of Gujranwala City Rapid industrialization and urbanization reinforced the evolution of emerging contaminants as industrial wastes from power plants, metallurgical industries, mining and refinery projects, coal and thermal processing industries posing serious health hazards for human beings as well as other living things mainly contributing to air, water and land pollution. These toxic pollutants are capable of persistent accumulation, biomagnifications and transportation to far off places with water. Once these toxic pollutants adsorb in soil they persevere for longer periods of time as metals are of non-biodegradable nature thus affect physiochemical nature of ground water as well as soil. In this research study soil and ground water samples were collected from landfills in the vicinity of Industrial Estate-1, Industrial Estate-2 and Drain. Experimentation was carried out by analysis of toxic metals using AAS (AA-6300), measured concentrations of Cu, Zn, Ni, Cr, Cd, Fe and Mn in ground water and soil samples thrice in almost a year (November-2017, March-2018 and July-2018). Results obtained were compared to threshold or background values which predominated in brackets that maximum values for Soil samples as Mn: 6627 mg/Kg (950 mg/Kg), Cd: 3171.40 mg/Kg (0.09 mg/Kg), Cr: 14019.05 mg/Kg (92 mg/Kg), Ni: 6177 mg/Kg (47 mg/Kg), Cu: 12682.50 mg/Kg (28 mg/Kg) and Zn: 7618 mg/Kg (67 mg/Kg) whereas for ground water samples as Mn: 3.91 mg/L (0.5 mg/L), Cd: 2.36 mg/L (0.01-0.03 mg/L), Cr: 5.01 mg/L (0.05 mg/L) and Ni: 0.87 mg/L (0.02 mg/L). pH of soil samples ranged from 6.9 to 9.6 which shows basicity level increased and pH of water samples found in range 6.8 to 7.3 exceeded the threshold pH value (7.0). Elevated levels found in soil and ground water samples depicted potential health risks associated with these contaminants and higher exposure rate to population inhabiting the vicinity of industrial landfills. Lack of proper management for disposal sites increased exposure to toxic metal pollutants. | 2018 |
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1. Hassan, A.U., Sumrra, S.H., Zubair, M., Mustafa,G., Noreen, S., Imran,M. “Correlating the charge density and structural fabrication of new organic dyes to create visible light harvesting materials with tunable NLO refining: insights from DFT” Chemical Papers, June 2023 DOI: https://doi.org/10.1007/s11696-023-02931-z
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2. Hassan, A. U., Sumrra, S. H., Mustafa, G., Noreen, S., Ali, A., Sara, S., & Imran, M. “Enhancing NLO performance by utilizing tyrian purple dye as donor moiety in organic DSSCs with end capped acceptors: A theoretical study” Journal Of Molecular Graphics & Modelling, June 2023 DOI: https://doi.org/10.1016/j.jmgm.2023.108538
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3. Noreen, S., Sumrra, S. H., Chohan, Z. H., Mustafa, G., & Imran, M. “Synthesis, characterization, molecular docking and network pharmacology of bioactive metallic sulfonamide-isatin ligands against promising drug targets.” Journal Of Molecular Structure, April 2023 DOI: https://doi.org/10.1016/j.molstruc.2022.134780
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4. Asfhaq, M., Li, Y., Zubair, M., Ur Rehman, M ,S., Sumrra, S. H., Nazar, M. F., Sun, Q., “Occurrence and risk evaluation of endocrine-disrupting chemicals in wastewater and surface water of Lahore, Pakistan” Environmental Geochemistry And Health, March 2023 DOI: https://doi.org/10.1016/j.jmgm.2023.108538
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5. Hassan, A. U., Sumrra, S. H., Mustafa, G., Zubair, M., Mohyuddin, A., Nkungli, N. K., & Imran, M. “Molecular modeling of mordant black dye for future applications as visible light harvesting materials with anchors: design and excited state dynamics. ” Journal Of Molecular Modeling, February 2023 DOI: https://doi.org/10.1007/s00894-023-05474-y
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6. Mustafa, G., Zia-ur-Rehman, M., Sumrra, S. H., Ashfaq, M., Zafar, W., & Ashfaq, M. “A critical review on recent trends on pharmacological applications of pyrazolone endowed derivatives. ” Journal Of Molecular Structure, August 2022 DOI: https://doi.org/10.1016/j.molstruc.2022.133044
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7. Sumrra, S. H., Hassan, A. U., Zafar, M. N., Shafqat, S. S., Mustafa, G., Zafar, M. N., Zubair, M., & Imran, M. “Metal incorporated sulfonamides as promising multidrug targets: Combined enzyme inhibitory, antimicrobial, antioxidant and theoretical exploration” Journal Of Molecular Structure, February 2022 DOI: https://doi.org/10.1016/j.molstruc.2021.131710
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8. Ashfaq, M., Li, Y., Rehman, M. S. U., Zubair, M., Mustafa, G., Nazar, M. F., ... & Sun, Q. “Occurrence, spatial variation and risk assessment of pharmaceuticals and personal care products in urban wastewater, canal surface water, and their sediments: A case study of Lahore, Pakistan” Science Of The Total Environment, October 2019 DOI: https://doi.org/10.1016/j.scitotenv.2019.06.285
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9. Mustafa, G., Angeli, A., Zia-ur-Rehman, M., Akbar, N., Ishtiaq, S., & Supuran, C. T. “An efficient method for the synthesis of novel derivatives 4-{5-[4-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-yl)-phenyl]-3-trifluoromethyl-pyrazol-1-yl}-benzenesulfonamide and their anti-inflammatory potential” Bioinorganic Chemistry And Applications, July 2019 DOI: https://doi.org/10.1016/j.bioorg.2019.103110
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10. Sumrra, S. H., Ramzan, S., Mustafa, G., Ibrahim, M., Mughal, E. U., Nadeem, M. A., ... & Khalid, M. “Complexes of Imino-1,2,4-triazole Derivative with Transition Metals: Synthesis and Antibacterial Study” Russian Journal Of General Chemistry, October 2018 DOI: https://doi.org/10.1134/S1070363218080248
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11. Mustafa, G., Zia-ur-Rehman, M., Khan, I. U., Ishtiaq, S., Hussain, S., Arshad, M. N., & Asiri, A. M. “Novel 4-[5-{4-[(2-Benzylidenehydrazine)Carbonyl]phenyl}-3-(Trifluoromethyl)-1H-Pyrazol-1-yl]Benzenesulfonamides: Synthesis, Crystal Structure, Anti-Inflammatory and Ulcerogenecity Studies” Journal Of Chemical Research, March 2016 DOI: https://doi.org/10.3184/174751916X14552786665833
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12. Ashfaq, M., Khan, K. N., Rasool, S., Mustafa, G., Saif-Ur-Rehman, M., Nazar, M. F., Sun, Q, & Yu, C. P. “Occurrence and ecological risk assessment of fluoroquinolone antibiotics in hospital waste of Lahore, Pakistan” Environmental Toxicology And Pharmacology, December 2015 DOI: https://doi.org/10.1016/j.etap.2015.12.015
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13. Jassas ,R ,S., Asiri, A ,M., Arshad ,M, N., Zayed ,M., Mustafa ,G., “Crystal structure of 1-benzoyl-3-(4- fluorophenyl)thiourea” Acta Crystallographica Section E-Crystallographic Communications, August 2014 DOI: DOI:10.1107/S1600536814018376
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14. Ashfaq, M., Akhtar, T., Mustafa, G., Danish, M., Razzaq, S. N., & Nazar, M. F. “Simultaneous estimation of rosuvastatin and amlodipine in pharmaceutical formulations using stability indicating HPLC method” Brazilian Journal Of Pharmaceutical Sciences, February 2014 DOI: https://doi.org/10.1590/S1984-82502014000300023
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15. Asiri, A. M., Arshad, M. N., Obaid, A. Y., & Mustafa, G. “5-Acetyl-3-(5-phenyl-1H-pyrazol-3-yl)-1, 3, 4-thiadiazol-2 (3H)-one monohydrate.” Acta Crystallographica Section E-Crystallographic Communications, April 2013 DOI: https://doi.org/10.1107/S1600536813010817
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16. Ashfaq, M., Iram, S., Akkurt, M., Khan, I. U., Mustafa, G., & Sharif, S. “4-[(4-Methylbenzenesulfonamido)methyl]cyclohexanecarboxylic acid” Acta Crystallographica Section E-Crystallographic Communications, October 2011 DOI: https://doi.org/10.1107/S1600536811020083
-
17. Ashfaq, M., Iram, S., Akkurt, M., Khan, I. U., Mustafa, G., & Danish, M. “4-[(4-Methoxybenzenesulfonamido)methyl]cyclohexane-1-carboxylic acid” Acta Crystallographica Section E-Crystallographic Communications, March 2011 DOI: https://doi.org/10.1107/S1600536811030650
-
18. Mustafa, G., Tasneem, S., Khan, I. U., Ashfaq, M., & Arshad, M. N “Benzyl 2-{4-[2-(4-chlorobenzoylamino)ethyl]phenoxy}-2-methylpropionate” Acta Crystallographica Section E-Crystallographic Communications, March 2011 DOI: https://doi.org/10.1107/S1600536811030650
-
19. Mustafa, G., Akkurt, M., Khan, I. U., Naseem, R., & Sajjad, B. “N-{[4-(4-Methoxybenzenesulfonamido)phenyl]sulfonyl}acetamide” Acta Crystallographica Section E-Crystallographic Communications, June 2010 DOI: https://doi.org/10.1107/S1600536810023925